LPS are subcategorized into three main groups, including WDLPS/DDLPS, characterized by a typical MDM2 and high-mobility group AT-hook 2 (HMGA2) gene amplification and an inconsistent CDK4 gene amplification (the 12q amplicon can span chromosomal regions from 12q12 up to 12q21); myxoid/round cell liposarcoma (M/RCLPS), carrying a typical t (12, 16)(q13;p111) translocation, and pleomorphic liposarcoma (PLPS), frequently showing TP53 and/or RB gene losses. The gene discussed is HMGA2; the disease is pleomorphic liposarcoma.