DUX4 rearrangements have been identified in specific types of pediatric B cell acute lymphoblastic leukemia (30, 31), in small round cell bone and soft tissue sarcomas – the so-called CIC-DUX4 rearranged family of sarcomas (32, 33), and rhabdomyosarcoma (34). The gene discussed is DUX4; the disease is soft tissue sarcoma.