Tumoral fibrosis was significantly increased in 64Cu-DOTHA2-PSMA and 177Lu-PSMA-617 groups in comparison to natCu-DOTHA2-PSMA (p < 0.001 for both) and to non-treated mice for 64Cu-DOTHA2-PSMA (p = 0.005) (Figure 4N). This evidence concerns the gene FOLH1 and neoplasm.