RPS6KA2 and familial pancreatic carcinoma: RPS6KA2 was first isolated in 1994 and encoded a protein of approximately 90 kDa that acts downstream of MAP kinases to transduce a variety of signals from the cell surface induced by growth factors or stress to the nucleus (35, 36).RPS6KA2 has been confirmed to play an important role in prostate cancer, pancreatic cancer, colon or rectal cancer (37–39).