Angiopoietin‐1 (Angpt1) reduces plasma leakage by activating Tie2 signaling (Thurston et al, 2000; Claesson‐Welsh et al, 2021), but compared with VE‐PTP, targeting the Angpt1‐Tie2 system has more complex effects in the context of atherosclerosis (Theelen et al, 2015; Fujisawa et al, 2017; Ou et al, 2020). The gene discussed is PTPRB; the disease is atherosclerosis.