ABCB1 and cancer: Furthermore, TAX reduced the expression of ATP-binding cassette subfamily B member 1 (ABCB1) and the function of P-glycoprotein (P-gp) via uncompetitive inhibition of rhodamine 123 and doxorubicin efflux, suggesting that TAX might be useful for multiple drug resistance (MDR) to chemotherapeutic agents in cancer [65].