Including the two consultation cases in this study, all epithelioid-AMLs with TFE3 gene amplification were female and all had poor prognoses with tumor recurrence/metastasis within a year of surgery, raising the probability that epithelioid-AMLs with TFE3 gene amplification may constitute a distinctive subset of PEComa. This evidence concerns the gene TFE3 and neoplasm with perivascular epithelioid cell differentiation.