It has been demonstrated that FYN directly phosphorylates CD147 at Y140 and Y183, while CD147-FF (Y140F/Y183F) mutation impairs the interaction between CD147 and FYN, and knockdown of FYN expression significantly attenuates the malignant phenotype of melanoma cells by downregulating CD147 phosphorylation [91, 92]. This evidence concerns the gene FYN and melanoma.