Two primary targets were selected for CRISPR‐Cas9 mediated knockout (KO) due to their high frequency of deletion in PM; NF2, to explore its role as a principal regulator of the Hippo pathway and BAP1, in order to assess its impact on YAP/TAZ activity, as well as more broadly, the effect of its loss on cancer progression, in the context of mesothelioma. Here, YAP1 is linked to mesothelioma.