BAP1 and familial pancreatic carcinoma: Although we present evidence that BAP1 loss in certain instances may be involved in partially activating the Hippo transcriptional module (Figures S2B and S4D), the mechanism by which this is effected in vitro in mesothelial cells is unclear, though not mediated via degradation of LATS proteins as previously described within the pancreatic cancer context48 (Figure S3G,H).