IFNG and neoplasm: For example, long‐circulating fusion proteins of IL‐12 have shown high levels of serum IFN‐γ[74, 75] and IL‐12 immunocytokines have shown accumulations to off‐target site.[76, 77] The ability of Nano‐IL‐12 to control the spatiotemporal activation could provide a safe and potent strategy with specificity in tumor targeting.