CD8A and clear cell renal carcinoma: To determine whether the enrichment of exhausted CD8+ T cells with high expression of CXCL13 is correlated with better efficacy of immune checkpoint blockade (ICB), we collected two public scRNA-seq datasets with ICB response information55,56 and found that exhausted CD8+ T cells were more prevalent in patients sensitive to ICB than in those resistant to ICB in bladder cell carcinoma (BCC) and clear cell renal cell carcinoma (ccRCC) (Supplementary Fig. 7).