IFNG and neoplasm: Moreover, the primary tumours of the hematogenous route predicted via the radiomics model had higher IFN-α (NES = 2.4, FDR < 0.001) and IFN-γ (NES = 2.2, FDR < 0.001) response pathway activities than those of the lymphatic route (Fig. 6h), which was consistent with previous results based on samples with genomic evidence.