To determine whether the enrichment of exhausted CD8+ T cells with high expression of CXCL13 is correlated with better efficacy of immune checkpoint blockade (ICB), we collected two public scRNA-seq datasets with ICB response information55,56 and found that exhausted CD8+ T cells were more prevalent in patients sensitive to ICB than in those resistant to ICB in bladder cell carcinoma (BCC) and clear cell renal cell carcinoma (ccRCC) (Supplementary Fig. 7). This evidence concerns the gene CD8A and nonpapillary renal cell carcinoma.