Furthermore, the bulk RNA-seq data showed that primary tumours of the lymphatic route were significantly enriched in pathways such as EMT (NES = 2.1, FDR < 0.001), UV response (NES = 1.7, FDR = 0.006) and angiogenesis (NES = 1.5, FDR = 0.001), while primary tumours of the hematogenous route were significantly enriched in the interferon-alpha (IFN-α) (NES = 2.4, FDR < 0.001) and interferon-gamma (IFN-γ) (NES = 1.9, FDR < 0.001) response pathways (Fig. 5c). Here, IFNG is linked to neoplasm.