TP53 and neoplasm: To validate the accuracy of the radiomics prediction model, we strived to obtain additional matched primary, regional lymph node and metastases tumours (P49-P53) and then constructed genomic phylogenetic trees and predicted the metastatic route using the radiomics prediction model synchronously, which showed that the phylogenetic trees based on genomic data were concordant with the results of the radiomics prediction (Fig. 6i; Supplementary Fig. 9d; Supplementary Fig. 10a).