In addition, patients with IDH-mutant astrocytomas CNS WHO grades 2–4 had significantly more DMPs compared to patients with oligodendrogliomas CNS WHO grade 2–3 (mean DMPs 51,700 and 29,200, respectively, p-value = 0.01045, Fig. 5C). Here, IDH1 is linked to astrocytoma (excluding glioblastoma).