The 5xFAD mice show initial weight loss and cognitive deficits at 6-months of age18,60, with severe deficits and increased mortality by 12-months of age, especially in males61, providing a useful model to study age-related expression patterns of Igf2 and IGF2 in central, peripheral, and circulatory systems in response to Aβ accumulation. The gene discussed is IGF2; the disease is Cognitive impairment.