The 5xFAD mice showed significantly higher Aβ42 binding in the plasma than WT mice, and there were genotype by age and genotype by sex interactions: Aβ42 association with the Igf2 promoter increased in 5xFAD mice as they aged, and the increase was greater in 5xFAD females than males (Fig. 3e), suggesting that cfDNA epigenetic marks at transcription factor binding sites in plasma also reflect age-related AD pathologies. The gene discussed is IGF2; the disease is Alzheimer disease.