IGF2 and Alzheimer disease: Our findings show that the levels of IGF2 and Igf2 mRNA expression were lower in the frontal cortex of AD than non-AD patients and lower in females than males (Fig. 4a,b), with the sex differences driven by H19 ICR DNA methylation (Fig. 4c with S2b), whereas genotype differences were driven by Aβ42 bound to the Igf2 DMR2 (Fig. 5c), independent of the levels of H19 ICR DNA methylation (compare Figs. 5c with 4c and S2b).