Overall, these findings (see Fig. S2 and Table S3 for statistical analyses) show that males had higher levels of H19 ICR DNA methylation than females, with no effect of AD, and that CTCF association was higher in non-AD females than non-AD males (Fig. S2b), with no AD- or sex-differences in H3K9ac or H3K9me3 (Fig. S2c,d). Here, CTCF is linked to Alzheimer disease.