AXIN2 and uveitis: To determine the activation status of Wnt/β-catenin signaling in uveitis, EAU was induced in mice and the expression of β-catenin and Wnt target genes (Lef1, Sox9, Axin2, and Tcf1) measured at different stages of EAU, including the induction phase (days 1 and 5 post-immunization; D1 and D5), onset phase (day 12 post-immunization; D12), and peak phase (days 18 and 25 post-immunization; D18 and D25) (Fig. 1a).