BRD2 and ovarian dysfunction: Hence, the overlap of different signaling pathways not only provides the opportunity for (improved) cross-talk between gonadotropin and growth factor signaling pathways and in order to enhance intracellular signaling in the GCs and compensate the decreased FSH levels in FL1 mice, it furthermore has the potential to preserve FL1 mice from the negative effects of high FSH levels such as accelerated reproduction failure, premature infertility and ovarian failure [16, 43].