The correlation between the mRNA expression of HIF-2α and these 15 potential target genes in ccRCC was identified from the TCGA database (Fig. 2A), including EGLN3, VEGFA, SEMA6A, and ADM. Among these, VEGFA is a well-known HIF-2α target gene and EGLN3 positively regulates the mRNA expression of HIF-2α [24]. This evidence concerns the gene EGLN3 and nonpapillary renal cell carcinoma.