Interestingly, ccRCC is triggered by the biallelic inactivation of the tumor suppressor gene Von Hippel-Lindau (VHL) in renal epithelial cells, which deregulates the hypoxia-inducible factors (HIFs), including HIF-1a and HIF-2α [10, 11]. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.