MFN2 and acute myeloid leukemia: To investigate the mechanisms underlying the anti-leukemic activity of mitochondrial fusion inhibition, we performed differential gene expression (DGE) analysis in transcriptomes of PDX samples and human AML cell lines after inhibition of MFN2 or OPA1, and we observed that the most significantly depleted signatures were related to cell cycle regulation (Fig. 3A and Supplementary Fig. S3A–C).