To determine whether Cre+FLT3ITD/ITD AML was driven by broad changes in gene expression that were concordant across different Cre genotypes, we interrogated RNA-sequencing on Kit+ populations from Scl-CreERT:FLT3ITD/ITD spleen and BM and Mx1-Cre:FLT3ITD/ITD BM compared to FLT3ITD/ITD controls. This evidence concerns the gene KIT and acute myeloid leukemia.