Since high doses of APR-246 induced lytic death in Eμ-Myc lymphoma cells, even those deficient for BAX and BAK, we examined whether NINJ1 was involved in the APR-246 induced lysis of these cells by deleting NINJ1 using CRISPR/Cas9 in both wt and BAX/BAK deficient Eμ-Myc lymphoma cells (both expressing wt TRP53). The gene discussed is BAX; the disease is lymphoma.