The human U937 histiocytic lymphoma cell line and the HT29 colon cancer cell line (Supplementary Table 1: U937 (TP53 deficient) and HT29 (R273H)) were selected for these studies since they express RIPK1, RIPK3 and MLKL and are able to undergo necroptosis [20, 48]. This evidence concerns the gene MLKL and malignant colon neoplasm.