Live cell imaging confirmed that upon treatment with high doses (50 μM) of APR-246, NINJ1-deficient as well as BAX/BAK/NINJ1 triple knockout Eμ-Myc lymphoma cells did not show signs of cell lysis, although cell death could still be observed as evidenced by staining with PI (Supplementary Fig. S9 and Supplementary movies 3 and 4). Here, NINJ1 is linked to lymphoma.