Using CRISPR/Cas9 we engineered wt TRP53 Eμ-Myc lymphoma cells to either lack all three BH3-only proteins, BIM, PUMA and NOXA (collectively required to initiate DNA damage-induced killing of Eμ-Myc lymphoma cells [44]) or BAX and BAK the essential effectors of apoptosis [45] (Fig. 4c–e). The gene discussed is BBC3; the disease is lymphoma.