Moreover, we used the AH15A and AF47A wt Trp53 Eμ-Myc lymphoma cell lines to generate isogenic background cells with all four possible TRP53 states, namely wt TRP53, wt TRP53 alongside R270H mutant TRP53 (expressed from a retroviral vector), wt Trp53 knockout and wt Trp53 knockout alongside R270H mutant TRP53 (expressed from a retroviral vector) (Supplementary Fig. S1a). The gene discussed is TP53; the disease is lymphoma.