Interestingly, there were profound differences in expression levels of cytokines/factors between dogs with mild/moderate and advanced babesiosis: the highest expression of STAT4, GATA3 and IL-10 was detected in group Babesia 1, while INF-γ, STAT6 and SOCS3 were expressed at a higher level in group Babesia 2. This evidence concerns the gene SOCS3 and babesiosis.