This is particularly relevant in Parkinsonism where mutations in the key CME-regulators Auxilin (DNAJC6, PARK19), Synaptojanin-1 (SYNJ1, PARK20) and EndophilinA-1 (SH3GL2) were identified to cause disease, and also other accessory regulatory proteins to CME like LRRK2, RME-8, GAK (Auxilin-II) are implicated7–12. This evidence concerns the gene SYNJ1 and Parkinson disease.