Studies have reported that IL-6, TNF-α, CRP, YKL-40, IL-17, IL-1β, CCL2, IL-2, and IL‐8 are related to worse cognitive function or cognitive deterioration, while CRP, TNF-α, sIL-2R and CCL2 reflect severe symptoms of depression and anxiety. The gene discussed is CHI3L1; the disease is major depressive disorder.