Although there have been studies on the influence of DCDC2 methylation on the prognosis of hepatocellular carcinoma (HCC) patients and paclitaxel resistance [10, 11], no evidence has confirmed the biological role of DCDC2 in colorectal cancer or the correlation between DCDC2 and the Wnt pathway in tumors. The gene discussed is DCDC2; the disease is colorectal cancer.