It is worth noting that the Waardenburg syndrome type 4 mouse model combines abnormal development of the ENS (causing aganglionic megacolon), which showed that ENCC‐derived ENS progenitors failed to reach the distal colon due to up‐regulated NR2F1 inducing premature differentiation in enteric glial cells.54 The gene discussed is NR2F1; the disease is Waardenburg-Shah syndrome.