To the best of our knowledge, MS147 is the first and only BMI1 and RING1B degrader, which selectively degrades PRC1 components, BMI1 and RING1B, over PRC2 components: EED, EZH2, and SUZ12 and effectively suppresses the proliferation in cancer cells that are insensitive to EZH2 knockout or EED/PRC2 degraders. This evidence concerns the gene RNF2 and cancer.