KEGG pathway enrichment analysis showed that treating OPF with BZYQD was mainly related to chemical carcinogenesis-receptor activation, lipid and atherosclerosis, estrogen signaling pathway, osteoclast differentiation, TNF signaling pathway, endocrine resistance, reactive oxygen species, HIF-1 signaling pathway, NF-κB signaling pathway, and MAPK signaling pathway (Fig. 5B). The gene discussed is TNF; the disease is atherosclerosis.