BRD4 and Miyoshi myopathy: Given the propensity of BRDs to bind acetylated lysines in histone tails, and their co-occupancy at open chromatin (as evident with the DHS signal) peaks, we used an inhibitor of BRD4 (BRD4i) to suppress the expression of ITGB7. JQ1, a BET-BRD4i has previously been shown to possess anti-proliferative and anti-apoptotic effects against the MM cells [40] We treated MM.1S cells with JQ1, at concentrations from 25 nM to 2 μM and determined cell viability at 24, 48, and 72 h.