A Meta analysis performed by Dadhania et al. [23] on large cohorts including 937 bladder cancer tissue samples showed that immunohistochemical expression of only two markers, one luminal specifically GATA3 and CK5/6 as basal are sufficient to classify bladder cancers into luminal and basal types with over 90% accuracy. The gene discussed is KRT5; the disease is urinary bladder cancer.