We found that PDE4B and CDK8 were highly expressed in GC cell lines compared to GES1, especially in HGC27 and MGC803, which was opposite to the expression of miR-26b-5p in GC cell lines suggesting that miR-26b-5p negatively regulates PDE4B and CDK8 (Fig. 4A–B). Here, PDE4B is linked to gastric cancer.