IL7 and Sepsis: However, it has also been reported that the activation of JAK-STAT3/NF-κ B pathway can enhance the host inflammatory response, and application of recombinant human interleukin-7 (RHIL-7) can increase the expression of STAT3/NF-κ B signaling pathway during the immunosuppression stage of sepsis, thus enhancing the clearance of pulmonary pathogens in CLP-induced sepsis [27].