The positivity of AMs (CD38 and HLA-DR) and IMs (PD-1, TIM-3, CTLA-4, BTLA and LAG-3) on CD4+ and CD8+T cells in the peripheral blood of patients with GC was significantly higher than that in the peripheral blood of HDs (Fig. 2A). The gene discussed is PDCD1; the disease is gastric cancer.