Multivariate analysis showed that the positivity of TIM-3+CD8+PBLs (HR: 0.134, 95% CI 0.037–0.485, P = 0.002) and PD-L1+CD8+PBLs (HR: 4.309, 95% CI 1.738–10.682, P = 0.002) were independent protective and risk factors for GC, respectively (Table 2). This evidence concerns the gene CD274 and gastric cancer.