NMOSD- AQP4 + clinical manifestations include severe optic neuritis (longitudinally extensive involvement of either unilateral or bilateral optic nerves often with chiasmal involvement), longitudinally extensive transverse myelitis, area postrema syndrome with intractable nausea/emesis, diencephalic involvement with altered mental status and endocrine disturbances, and hemispheric syndrome. Here, AQP4 is linked to optic neuritis.