A similar search of DR17 using the term microphthalmia resulted in 22 genes significant for the small eyes phenotype: Aldh1a3, Aff4, Bmp4, Cdk4, Cox6b1, Cxcr4, Dync1li1, Eef1d, Fgd1, Gne, Grh12, Mab21l2, Maf, Med13l, Mllt10, Mthfd2, Pex6, Phgdh, Ssr1, Stim1, Tdo2, and Vps26c (Fig. 2). This evidence concerns the gene CDK4 and microphthalmia.