HESX1 and Septo-optic dysplasia: Among the 15 genes with published eye phenotypes, 9 of the lines from the IMPC program had eye phenotypes similar to that of published mouse models (Axin2, Adh1a3, Bcl11b, Fuz, Inpp5e, Mab21l2, Maf, Pax6, Pygo2); the remaining 5 lines resulted in embryonic eye phenotypes (Acvr2a, Bmi1, Dnmt3b, Dync1li1, Hesx1) more severe than the phenotypes of extant models which consisted of septo-optic dysplasia (Hesx1), abnormal retinal vascularization (Acvr2a), and retinal and/or photoreceptor degeneration (Bmi1, Dnmt3b, Dync1li1).