NR1H4 and acute kidney injury: In a comparative study on cisplatin-induced AKI in WT and FXR KO mice, the levels of serum creatinine, blood urea nitrogen, and kidney tubular injury in the FXR KO-cisplatin group were significantly higher than those in the WT-cisplatin group; furthermore, FXR deficiency aggravated cisplatin-induced AKI, possibly by inhibiting autophagy and promoting apoptosis53.