NR1H4 and chronic kidney disease: In CKD rat models and human aortic smooth muscle cells (HASMCs) cultured with osteogenic medium, FXR activation increases the expression of miR-135a-5p, which inhibits the transforming growth factor-β (TGFβ) receptor 1 (TGFBR1)/TGF-β-activated kinase 1 (TAK1) pathway and attenuates vascular calcification40.