In Akita and OVE26 mice, which are genetic mouse models of type 1 diabetes mellitus, the expression levels of FXR, SHP, PPARα, and PPARδ decrease in the kidneys compared with those of the WT; conversely, the levels of triglyceride and cholesterol and the expression of SREBP-1c and ChREBP, which increase fatty acid synthesis, increase29. Here, NR1H4 is linked to diabetes mellitus.