Despite the fact that deciphering the detailed activity of the ubiquitination process is essential for paving the underlying roles of PPAR α/γ1 in the pathogenesis of diabetic cardiomyopathy, the lysine site(s) that MuRF1/MuRF2 targets for ubiquitinating cardiac PPAR α/γ1 remains unknown. This evidence concerns the gene TRIM63 and diabetic cardiomyopathy.