CCN3 has been shown to act as a metastasis inducer by promoting the migration of cancer cells in glioblastoma, Ewing’s sarcoma, melanoma, chondrosarcoma, prostate cancer, clear cell renal cell carcinoma, and hepatocellular carcinoma [5, 7, 8, 10, 12, 13, 16, 43, 44]. Here, CCN3 is linked to melanoma.