The pathogenic effect of in utero exposure to anti-aquaporin-4 (Aqp4) IgG1 cloned from a patient with Neuromyelitis Optica depends on the presence of the non-glycosylated form of Aqp4 in the embryonic brain and is mediated by complement-dependent cytotoxicity, since pathology is absent in mice lacking the complement component C1q [38]. The gene discussed is AQP4; the disease is neuromyelitis optica.