Moreover, while CDKL5 KO mice have demonstrated increased susceptibility to seizure generation [39, 76], the absence of early-life spontaneous and recurrent seizures in this animal model allowed us to identify the consequence of CPN dysfunction independently from severe spontaneous seizures; suggesting that seizures alone are not responsible for the developmental perturbations and cognitive impairment described in CDD patients. Here, CDKL5 is linked to Cognitive impairment.