Among the 52 inflammatory/immune proteins positively correlated with EDII score, six proteins (CXCL10, CCL3, HGF, OPG, CDCP1, NFATC3) were significantly associated with increased odds of incident cognitive impairment after adjusting for demographic characteristics and cardiovascular risk factors (Fig. 3A). This evidence concerns the gene CCL3 and Cognitive impairment.