NEFL and Cognitive impairment: Similarly, the apoptotic process composite score, which was associated with a greater EDII score and incident cognitive impairment, also maintained a significant positive correlation with NfL (rho = 0.10, p < 0.001) and Aβ42/40 (rho = 0.19, p < 0.001) after adjusting for age (Supplementary Table 14).