Our 3′aTWAS results not only confirmed previously reported APA risk genes (SNCA and DDHD2) but also identified previously unknown APA-linked susceptibilities genes, such as ZNF592 and ATXN3. Further analysis revealed that 3′aTWAS-identified genes are not a random set of genes but are enriched in previously reported pathways related to brain disorders. This evidence concerns the gene ZNF592 and brain disorder.