The use of neutrophil antibodies to induce neutropenia can effectively suppress AAA.163 In an elastase-induced AAA mouse model, ECs release the family with sequence similarity 3, member D (FAM3D), which promotes the recruitment of peripheral blood neutrophils to the abdominal aorta by activating the downstream protein kinase C (PKC), ERK, and p38MAPK pathways through the activation of membrane attack complex-1 (Mac-1) and formyl peptide receptor 2 (FPR2) in neutrophils, thereby inducing the development of AAA.164. Here, FAM3D is linked to triple-A syndrome.