AGT and triple-A syndrome: Daugherty et al. first reported in 1999 that subcutaneous infusion of Ang-II with a slow-release pump at a dose of 0.5 or 1 μg/min/kg for 28 days induced AAAs in ApoE-/- mice.316 Since then, hundreds of studies have used this model, which is the most commonly used modeling method for chemically induced AAA at present.