TIMP1 and triple-A syndrome: Four members of the TIMP family (TIMPs-1/2/3/4) can inhibit all MMPs and a large number of ADAMs through a covalent bond between their N-terminus and protease catalytic domains.89 AA has been observed in TIMP1 knockout mice90 and a significant decrease in TIMP-2 in the aortic wall of AAA patients.91 In a mouse model, aneurysms in TIMP-3 knockout mice were more prone to rupture, leading to death.92