IL1B and triple-A syndrome: Inhibition of IL-12 levels with antibodies could inhibit macrophages and thus AAA progression.145 TH17 cells are induced by stimulation of IL-23, IL-1, and IL-6 and promote macrophage activity by secreting IL-17.146 After knockdown of IL-17 in mice, the progression of AA was inhibited.147 Additionally, inhibition of AA was observed after inhibition of the pathway that activates TH17 cell differentiation.148