In particular, CD8+ T cells, as an important anti-tumor pioneer, are commonly affected by tumor metabolic microenvironment, leading to impaired cell proliferation, activation, and survival.2 Therefore, the investigation of metabolic interactions between tumor and CD8+ T cells in TME contributes to understand the pathophysiology and clinical metabolic phenotype of tumors, which is expected to provide a new theoretical basis for cancer treatment strategies targeting metabolic pathways. The gene discussed is CD8A; the disease is cancer.