TMEM105 and metastatic malignant neoplasm in the lymph nodes: Moreover, similar to the prognostic values of pathologic stage (II + III + IV versus I), tumor size (T3 + T4 versus T1 + T2), lymph node metastasis (N2-3 versus N0-1), M stage (M1 versus M0), age (>60 versus ≤60), PAM50 (LumB versus LumA), and PAM50 (Her2 versus LumA), the univariate regression analysis revealed that high TMEM105 expression was another effective predictive factor for poor OS (HR = 1.575, p = 0.006, Table 1).