In addition to a strong association with AKI, tau, a marker of injury to neuronal axon terminals, is elevated in circulation and correlated with AKI stages using the KDIGO criteria, as well as with markers of endothelial/cellular dysfunction (soluble vascular cell adhesion molecule 1, E-selectin, P-selectin, and angiopoietin 1) in both pediatric cerebral malaria and severe malarial anemia [52,53]. This evidence concerns the gene MAPT and cerebral malaria.