Interestingly, we identified four genes, Btg2, Egr1, Fos, and Atf3, associated with cardiac hypertrophy, in overlapping DEGs between the upregulated DEGs in PAH versus control groups and the downregulated DEGs in PAH/αKO versus PAH groups (Fig. 5D). The gene discussed is FOS; the disease is pulmonary arterial hypertension.