CA2 and glaucoma: Among the hCA isoforms, human carbonic anhydrase II (hCAII)is abundantly expressed and found to be broadly distributed in humantissues.5 As such, it has been exploredas a target in clinical treatments for indications including altitudesickness, edema, epilepsy, and glaucoma.9 Despite widespread clinical application for the treatment of glaucoma,14 none of the first or second generation FDA-approvedhCA inhibitors are isoform selective.