NFKB1 and cancer: In a related example, Nap-fff(py)-OMewas used as a substrate for EISA using ALP, including intracellularenzyme and this conjugate was used along with an NF-kB inhibitor BAYto provide synergistic cytotoxicity to cancer cells.187 The tetrapeptide conjugate fibrils themselves exhibitedlittle effect on cancer cell viability (although the conjugate lackingC-terminal methylation does).