DDX46 and viral infectious disease: For instance, DDX46 recruits ALKBH5, an “eraser” of the RNA modification N6-methyladenosine (m6A), via DDX46 DEAD helicase domain to demethylate m6A-modified antiviral transcripts after viral infection (42); DDX3X is recruited to the enhanceosome-binding site on the IFN-β promoter that is necessary for type I IFN induction (43).