Consequently, we have obtained a panel of mAbs (2H8A2, 20D5H6, and 26C7C9) that cross-reacted with both murine and human pCTS-L to inhibit its interaction with TLR4 and RAGE receptors, thereby rescuing mice from lethal sepsis even when the first dose was given in a delayed fashion. The gene discussed is TLR4; the disease is Sepsis.