The identification of GAL3-PODXL as a mutually repressive ligand-receptor pair, the balance of whose interplay affects integrin signaling, was unexpected as GAL1 association with the glycocalyx promotes ECM-integrin signaling in glioblastoma (3) and PODXL represses surface levels of β1-integrin in ovarian cancer cells (23). The gene discussed is LGALS1; the disease is glioblastoma.