The identification of GAL3-PODXL as a mutually repressive ligand-receptor pair, the balance of whose interplay affects integrin signaling, was unexpected as GAL1 association with the glycocalyx promotes ECM-integrin signaling in glioblastoma (3) and PODXL represses surface levels of β1-integrin in ovarian cancer cells (23). This evidence concerns the gene LGALS3 and glioblastoma.