Recently,the chemical conjugation of Glypromate dimethyl ester(60) with lipoic acid and peracetylated L/D configuration-DOPAwas shown to be a prolific strategy to explore synergistic effects,affording conjugates 80 and 81, respectively.While conjugate 80 was found to exhibit neuroprotectiveactivity (in vitro) using a cellular model of ADimproving the Aβ-induced AChE activity in comparison with Glypromate,conjugate 81 exhibited neuroprotective effects in ananimal model of PD. Here, ACHE is linked to Parkinson disease.