MMP9 and brain injury: Usingadult Wistar rats, it was shown that Glypromate can reachthe CNS after brain injury.14,15 This can be explainedby the activation of gelatinase matrix metalloproteinase MMP-2 (gelatinaseA) and MMP-9 (gelatinase B) in injured tissues, which digest the extracellularmatrix disrupting the organization of the cells and facilitating thepermeabilization of Glypromate across the blood–brain barrier(BBB).16 In this sense, Glypromate canfind application as a neuroprotective agent in brain injuries (e.g.,traumatic brain injury), as it is conditionally able to reach theaffected brain regions.14