Glypromate (glycyl-l-prolyl-l-glutamic acid, also known as GPE), an endogenous small peptidewidespread in the brain, holds great promise to tackle neurodegenerativediseases such as Parkinson’s, Alzheimer’s, and Huntington’s,s well as other CNS-related disorders like Rett and Down’ssyndromes. Here, GYPE is linked to Parkinson disease.